News
Containment at Scale: Managing High-Potency APIs Through Filtration and Drying
High-potency active pharmaceutical ingredients (HPAPIs) impose strict containment requirements that intensify during scale-up. When carrying out solid-liquid separation with HPAPIs, filtration and drying are containment risks as both can involve phase transitions, material exposure, and mechanical disturbance of the cake. At laboratory scale, these constraints are manageable, but at production scale they demand engineered solutions to maintain containment and ensure consistent performance. Safe scale-up depends on converting filtration and drying into closed, continuous operations that eliminate handling and ensure control throughout.
Phase 1: Benchtop Filtration and Drying with GFD®Lab
In early-stage development, filtration and drying are typically performed using Büchner funnels and laboratory tray dryers. While suitable for exploratory chemistry, these methods rely on manual handling of filter cakes, forming open exposure points that […]
The 7 Most Common Process Development Mistakes
The 7 most common process development mistakes and why scale-up can fail across filtration, drying, and agitation. Learn more.
What are Injectable Hydrogel Microspheres?
Injectable hydrogel microspheres are cross-linked polymer systems, enabling controlled drug release, biocompatibility, and scalable aseptic processing.
Maximising Product Recovery with a GFD® Filter Dryer Removable Basket
Product value is often inversely proportional to volume in pharmaceutical R&D and kilo-lab production. When synthesising a few hundred grams of a novel drug candidate, every milligram can represent weeks of experimentation, costly reagents, and the potential success of a clinical trial.
Yield loss during filtration and drying has long been accepted as an unavoidable reality. Product trapped in the filter mesh, heel remaining in the vessel, and inefficiencies in manual discharge have led to losses of 10–15% per batch, an expensive “tax” on progress.
At Powder Systems Ltd (PSL), we challenge that norm. Our GFD® (Glass Filter Dryer), featuring a unique removable filtration basket, redefines recovery efficiency at the lab scale. This design innovation removes operational imprecisions, providing complete control and measurable yield.
The Heel […]
How Pressure and Vacuum Filtration in ANFDs Improves Yield
Integrating pressure and vacuum filtration with mechanical agitation in a completely closed ANFD delivers high yield and product integrity.
Choosing a Modular Filter Dryer with Flexible Vessel Materials
Choose the right vessel material for your ANFD. Compare glass, stainless steel, and Alloy 22 in a modular filter dryer. Read more here.