Vacuum drying methods are a mainstay in chemical process industries (CPI), allowing sensitive materials to be dried without inhibiting critical properties. Intermediates and pre-clinical active pharmaceutical ingredients (APIs) tend to be heat-sensitive which makes them unsuitable for high-temperature convection processes.
Highly valuable compounds must be gently dried, otherwise, they may degrade. Any loss of quality across drug pipelines can naturally lead to wasted resources and higher costs. Hence the ubiquity of vacuum drying ovens in pharmaceutical labs, pilot plants, and commercial-scale labs.
Here we outline the basic working principles of vacuum drying processes, with a focus on how vacuum tray dryers work.